The last proposed mechanism of RBC vasodilation within the existence of nitrite may be the reduction of nitrite to NO by Hb. Brooks first studied the nitrite Hb conversation in 1937 which perform was later extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to kind metHb and NO (Brooks, 1937; Doyle et a